Drug interactions
Fenfluramine + Propofol
Severity: Minor
Fenfluramine and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is a serotonergic antiseizure drug that can cause somnolence, and no well-characterized interaction with propofol is established. Any additive effect would be a modest sedative one.
What this interaction means in plain words
Fenfluramine and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenfluramine belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
No established mechanism; possible modest additive CNS effects.
What to do
Titrate propofol to effect and monitor sedation and cardiovascular status. Continue fenfluramine per usual peri-procedural plans.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propofol
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Propofol?
MediHelp rates the interaction as minor. Fenfluramine and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenfluramine is a serotonergic antiseizure drug that can cause somnolence, and no well-characterized interaction with propofol is established. Any additive effect would be a modest sedative one.
How serious is the interaction between Fenfluramine and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and monitor sedation and cardiovascular status. Continue fenfluramine per usual peri-procedural plans.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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