Drug interactions
Fenofibrate + Iloperidone
Severity: Minor
Fenofibrate and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone inhibits CYP3A4, but fenofibrate is not mainly metabolized by this enzyme, so a meaningful rise in fenofibrate levels is unlikely.
What this interaction means in plain words
Fenofibrate and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Theoretical CYP3A4 inhibition by iloperidone with limited relevance to fenofibrate clearance.
What to do
No dose adjustment is needed. Routine monitoring is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Fenofibrate with Iloperidone?
MediHelp rates the interaction as minor. Fenofibrate and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone inhibits CYP3A4, but fenofibrate is not mainly metabolized by this enzyme, so a meaningful rise in fenofibrate levels is unlikely.
How serious is the interaction between Fenofibrate and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Routine monitoring is sufficient.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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