Drug interactions
Fenofibrate + Pravastatin
Severity: Moderate
Fenofibrate and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a fibrate with pravastatin may increase the risk of myopathy and rhabdomyolysis. Pravastatin has little CYP metabolism, so the risk is mainly additive muscle toxicity and is relatively low.
What this interaction means in plain words
Fenofibrate and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibrate belongs to Cardiovascular; Pravastatin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic myotoxicity of statin and fibrate.
What to do
Use the lowest effective doses and counsel patients to report muscle pain or weakness. Check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Fenofibrate with Pravastatin?
MediHelp rates the interaction as moderate. Fenofibrate and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a fibrate with pravastatin may increase the risk of myopathy and rhabdomyolysis. Pravastatin has little CYP metabolism, so the risk is mainly additive muscle toxicity and is relatively low.
How serious is the interaction between Fenofibrate and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients to report muscle pain or weakness. Check CK if symptoms occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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