Drug interactions
Fenofibrate + Rosuvastatin
Severity: Moderate
Fenofibrate and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining fenofibrate with rosuvastatin may modestly raise the risk of myopathy and rhabdomyolysis. Pharmacokinetic effects are small, so the concern is mainly additive muscle toxicity.
What this interaction means in plain words
Fenofibrate and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenofibrate belongs to Cardiovascular; Rosuvastatin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic myotoxicity.
What to do
Use the lowest effective doses and monitor renal function. Instruct patients to report muscle pain and check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Fenofibrate with Rosuvastatin?
MediHelp rates the interaction as moderate. Fenofibrate and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining fenofibrate with rosuvastatin may modestly raise the risk of myopathy and rhabdomyolysis. Pharmacokinetic effects are small, so the concern is mainly additive muscle toxicity.
How serious is the interaction between Fenofibrate and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor renal function. Instruct patients to report muscle pain and check CK if symptoms occur.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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