Drug interactions
Fenofibrate + Tazemetostat
Severity: Minor
Fenofibrate and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A4 inducer and could slightly lower exposure to CYP3A4 substrates. Fenofibrate is not a major CYP3A4 substrate, so a clinical effect is unlikely.
What this interaction means in plain words
Fenofibrate and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
Theoretical CYP3A4 induction by tazemetostat with limited relevance to fenofibrate.
What to do
No dose adjustment is needed. Reassess lipid response if efficacy appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Tazemetostat
Frequently asked questions
Can I take Fenofibrate with Tazemetostat?
MediHelp rates the interaction as minor. Fenofibrate and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak to moderate CYP3A4 inducer and could slightly lower exposure to CYP3A4 substrates. Fenofibrate is not a major CYP3A4 substrate, so a clinical effect is unlikely.
How serious is the interaction between Fenofibrate and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Reassess lipid response if efficacy appears reduced.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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