Drug interactions
Fenofibric acid + Levoketoconazole
Severity: Minor
Fenofibric acid and Levoketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor, but fenofibric acid is mainly glucuronidated and excreted renally, so exposure changes are expected to be small. Both agents can affect the liver and lipids.
What this interaction means in plain words
Fenofibric acid and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibric acid belongs to Cardiovascular; Levoketoconazole belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition by levoketoconazole affecting a minor pathway of fenofibric acid.
What to do
No fenofibric acid dose change is needed; monitor liver enzymes, as levoketoconazole carries hepatotoxicity risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Fenofibric acid with Levoketoconazole?
MediHelp rates the interaction as minor. Fenofibric acid and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levoketoconazole is a strong CYP3A4 inhibitor, but fenofibric acid is mainly glucuronidated and excreted renally, so exposure changes are expected to be small. Both agents can affect the liver and lipids.
How serious is the interaction between Fenofibric acid and Levoketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No fenofibric acid dose change is needed; monitor liver enzymes, as levoketoconazole carries hepatotoxicity risk.
What other medicines interact with Fenofibric acid?
MediHelp also lists interactions of Fenofibric acid with, for example, Atorvastatin, Chlorpropamide, Cholestyramine. The full list is on the Fenofibric acid page.
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