Drug interactions
Fenofibric acid + Rucaparib
Severity: Minor
Fenofibric acid and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 and other enzymes, but fenofibric acid is not mainly cleared by CYP3A4, so a significant increase in its levels is unlikely. The interaction is largely theoretical.
What this interaction means in plain words
Fenofibric acid and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibric acid belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
CYP3A4 inhibition by rucaparib affecting a minor elimination route of fenofibric acid.
What to do
No dose adjustment is required; monitor for fibrate adverse effects such as myalgia and raised liver enzymes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Fenofibric acid with Rucaparib?
MediHelp rates the interaction as minor. Fenofibric acid and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 and other enzymes, but fenofibric acid is not mainly cleared by CYP3A4, so a significant increase in its levels is unlikely. The interaction is largely theoretical.
How serious is the interaction between Fenofibric acid and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for fibrate adverse effects such as myalgia and raised liver enzymes.
What other medicines interact with Fenofibric acid?
MediHelp also lists interactions of Fenofibric acid with, for example, Atorvastatin, Chlorpropamide, Cholestyramine. The full list is on the Fenofibric acid page.
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