Drug interactions
Fenofibric acid + Stiripentol
Severity: Minor
Fenofibric acid and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol both inhibits and induces CYP3A4, but fenofibric acid is cleared predominantly by glucuronidation and renal elimination. Clinically relevant changes in fenofibric acid exposure are not expected.
What this interaction means in plain words
Fenofibric acid and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibric acid belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol affecting a minor pathway of fenofibric acid.
What to do
No dose adjustment is needed; monitor lipid response and liver tests periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Fenofibric acid with Stiripentol?
MediHelp rates the interaction as minor. Fenofibric acid and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol both inhibits and induces CYP3A4, but fenofibric acid is cleared predominantly by glucuronidation and renal elimination. Clinically relevant changes in fenofibric acid exposure are not expected.
How serious is the interaction between Fenofibric acid and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor lipid response and liver tests periodically.
What other medicines interact with Fenofibric acid?
MediHelp also lists interactions of Fenofibric acid with, for example, Atorvastatin, Chlorpropamide, Cholestyramine. The full list is on the Fenofibric acid page.
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