Drug interactions
Finerenone + Lomustine
Severity: Minor
Finerenone and Lomustine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Finerenone is a CYP3A4 substrate, and increased exposure raises the risk of hyperkalemia and renal effects. Lomustine is not an established CYP3A4 inhibitor, so any effect is theoretical.
What this interaction means in plain words
Finerenone and Lomustine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Finerenone belongs to Cardiovascular; Lomustine belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by lomustine, which is not well established.
What to do
Monitor serum potassium and renal function when starting or changing doses of either drug, adjusting finerenone as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Lomustine?
MediHelp rates the interaction as minor. Finerenone and Lomustine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Finerenone is a CYP3A4 substrate, and increased exposure raises the risk of hyperkalemia and renal effects. Lomustine is not an established CYP3A4 inhibitor, so any effect is theoretical.
How serious is the interaction between Finerenone and Lomustine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function when starting or changing doses of either drug, adjusting finerenone as needed.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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