Drug interactions
Finerenone + Progesterone
Severity: Minor
Finerenone and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone may modestly raise finerenone exposure through CYP3A4 inhibition. Higher finerenone levels increase the risk of hyperkalemia and renal function changes.
What this interaction means in plain words
Finerenone and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Finerenone belongs to Cardiovascular; Progesterone belongs to Endocrine.
Why it happens
Progesterone may weakly inhibit CYP3A4, reducing finerenone clearance.
What to do
Monitor serum potassium and renal function after starting or changing either drug. Adjust finerenone dose if potassium rises.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Finerenone with Progesterone?
MediHelp rates the interaction as minor. Finerenone and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progesterone may modestly raise finerenone exposure through CYP3A4 inhibition. Higher finerenone levels increase the risk of hyperkalemia and renal function changes.
How serious is the interaction between Finerenone and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function after starting or changing either drug. Adjust finerenone dose if potassium rises.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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