Drug interactions
Fluconazole + Leuprolide
Severity: Moderate
Fluconazole and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leuprolide, as a GnRH agonist causing androgen deprivation, may prolong the QT interval. With fluconazole, which also has QT liability, the arrhythmic risk may be additive.
What this interaction means in plain words
Fluconazole and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation; androgen deprivation is believed to contribute to leuprolide's effect.
What to do
Check a baseline ECG and correct electrolyte disturbances. Monitor ECG periodically in patients with cardiac risk factors or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Fluconazole with Leuprolide?
MediHelp rates the interaction as moderate. Fluconazole and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leuprolide, as a GnRH agonist causing androgen deprivation, may prolong the QT interval. With fluconazole, which also has QT liability, the arrhythmic risk may be additive.
How serious is the interaction between Fluconazole and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct electrolyte disturbances. Monitor ECG periodically in patients with cardiac risk factors or other QT-prolonging drugs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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