Drug interactions
Fluconazole + Maraviroc
Severity: Moderate
Fluconazole and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 substrate, and fluconazole modestly increases its exposure. This may enhance adverse effects such as postural hypotension and hepatotoxicity, but the effect is smaller than with strong inhibitors.
What this interaction means in plain words
Fluconazole and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Maraviroc belongs to Anti Virals.
Why it happens
Fluconazole inhibits CYP3A4, reducing maraviroc clearance.
What to do
Usually no dose change is needed with fluconazole alone; monitor for orthostatic hypotension and liver toxicity. Follow labeled dosing if other CYP3A4 inhibitors are also used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Fluconazole with Maraviroc?
MediHelp rates the interaction as moderate. Fluconazole and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc is a CYP3A4 substrate, and fluconazole modestly increases its exposure. This may enhance adverse effects such as postural hypotension and hepatotoxicity, but the effect is smaller than with strong inhibitors.
How serious is the interaction between Fluconazole and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no dose change is needed with fluconazole alone; monitor for orthostatic hypotension and liver toxicity. Follow labeled dosing if other CYP3A4 inhibitors are also used.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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