Drug interactions
Fluconazole + Montelukast
Severity: Minor
Fluconazole and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP3A4, CYP2C9 and CYP2C19, which are minor routes for montelukast, so exposure may rise slightly. Montelukast has a wide safety margin and clinical consequences are unlikely.
What this interaction means in plain words
Fluconazole and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Montelukast belongs to Respiratory.
Why it happens
Inhibition of minor CYP3A4 and CYP2C9 metabolic pathways of montelukast by fluconazole.
What to do
No dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Montelukast?
MediHelp rates the interaction as minor. Fluconazole and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole inhibits CYP3A4, CYP2C9 and CYP2C19, which are minor routes for montelukast, so exposure may rise slightly. Montelukast has a wide safety margin and clinical consequences are unlikely.
How serious is the interaction between Fluconazole and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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