Drug interactions
Fluconazole + Pacritinib
Severity: Major
Fluconazole and Pacritinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase pacritinib concentrations, which could heighten risks of diarrhea, bleeding, thrombocytopenia and QT prolongation. Pacritinib is a CYP3A4 substrate and fluconazole is also QT-prolonging.
What this interaction means in plain words
Fluconazole and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Pacritinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by fluconazole raises pacritinib exposure, with potential additive QT effects.
What to do
Avoid concurrent use and choose an antifungal without CYP3A4 inhibition. If it cannot be avoided, monitor ECG, electrolytes and platelet counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluconazole and Pacritinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Fluconazole with Pacritinib?
MediHelp rates the interaction as major. Fluconazole and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole may increase pacritinib concentrations, which could heighten risks of diarrhea, bleeding, thrombocytopenia and QT prolongation. Pacritinib is a CYP3A4 substrate and fluconazole is also QT-prolonging.
How serious is the interaction between Fluconazole and Pacritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an antifungal without CYP3A4 inhibition. If it cannot be avoided, monitor ECG, electrolytes and platelet counts closely.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
