Drug interactions
Fluconazole + Prochlorperazine
Severity: Moderate
Fluconazole and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can prolong the QT interval and inhibits CYP3A4 and CYP2C19, while prochlorperazine also affects repolarization. Together they raise the risk of QT-related arrhythmia.
What this interaction means in plain words
Fluconazole and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible metabolic inhibition raising prochlorperazine levels.
What to do
Check the ECG and electrolytes at baseline and during therapy, especially with high fluconazole doses. Consider an alternative antiemetic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Prochlorperazine?
MediHelp rates the interaction as moderate. Fluconazole and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can prolong the QT interval and inhibits CYP3A4 and CYP2C19, while prochlorperazine also affects repolarization. Together they raise the risk of QT-related arrhythmia.
How serious is the interaction between Fluconazole and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the ECG and electrolytes at baseline and during therapy, especially with high fluconazole doses. Consider an alternative antiemetic in patients with other QT risk factors.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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