Drug interactions
Fluconazole + Vilazodone
Severity: Moderate
Fluconazole and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole, a moderate CYP3A4 inhibitor, can increase vilazodone exposure, raising the risk of serotonergic and gastrointestinal adverse effects. Effects are usually dose-related and manageable.
What this interaction means in plain words
Fluconazole and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Vilazodone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated vilazodone metabolism by fluconazole.
What to do
Monitor for serotonin toxicity, nausea and other adverse effects. Reduce vilazodone to 20 mg daily if intolerable effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Fluconazole with Vilazodone?
MediHelp rates the interaction as moderate. Fluconazole and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole, a moderate CYP3A4 inhibitor, can increase vilazodone exposure, raising the risk of serotonergic and gastrointestinal adverse effects. Effects are usually dose-related and manageable.
How serious is the interaction between Fluconazole and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity, nausea and other adverse effects. Reduce vilazodone to 20 mg daily if intolerable effects occur.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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