Drug interactions
Fluphenazine + Porfimer
Severity: Moderate
Fluphenazine and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Porfimer is a photosensitizer used in photodynamic therapy, and phenothiazines can themselves cause photosensitivity. Use together may increase the chance or severity of skin phototoxic reactions after light exposure.
What this interaction means in plain words
Fluphenazine and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Porfimer belongs to Miscellaneous.
Why it happens
Additive photosensitizing effects of the two drugs.
What to do
Counsel strict avoidance of sunlight and bright indoor light for the period specified in porfimer labeling, and use protective clothing. Consider whether fluphenazine can be changed around the treatment period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Porfimer
Frequently asked questions
Can I take Fluphenazine with Porfimer?
MediHelp rates the interaction as moderate. Fluphenazine and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Porfimer is a photosensitizer used in photodynamic therapy, and phenothiazines can themselves cause photosensitivity. Use together may increase the chance or severity of skin phototoxic reactions after light exposure.
How serious is the interaction between Fluphenazine and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict avoidance of sunlight and bright indoor light for the period specified in porfimer labeling, and use protective clothing. Consider whether fluphenazine can be changed around the treatment period.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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