Drug interactions
Fluvoxamine + Givosiran
Severity: Moderate
Fluvoxamine and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can raise exposure to CYP1A2 and CYP2D6 substrates. Fluvoxamine is metabolized partly by CYP2D6, so levels may increase, causing more adverse effects such as nausea and sedation.
What this interaction means in plain words
Fluvoxamine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran reduces activity of CYP1A2 and CYP2D6, decreasing clearance of substrates.
What to do
Monitor for fluvoxamine adverse effects and reduce the dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Fluvoxamine with Givosiran?
MediHelp rates the interaction as moderate. Fluvoxamine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can raise exposure to CYP1A2 and CYP2D6 substrates. Fluvoxamine is metabolized partly by CYP2D6, so levels may increase, causing more adverse effects such as nausea and sedation.
How serious is the interaction between Fluvoxamine and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fluvoxamine adverse effects and reduce the dose if they occur.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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