Drug interactions
Fluvoxamine + Rolapitant
Severity: Minor
Fluvoxamine and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine is cleared mainly by CYP2D6 and CYP1A2, and rolapitant can inhibit CYP2D6 over a prolonged period. Fluvoxamine concentrations may increase somewhat, with greater nausea, sedation or serotonergic effects, though the clinical effect is probably small.
What this interaction means in plain words
Fluvoxamine and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, slightly reducing fluvoxamine metabolism.
What to do
No empirical dose change is needed. Monitor for fluvoxamine adverse effects and adjust the dose if they develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Rolapitant?
MediHelp rates the interaction as minor. Fluvoxamine and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine is cleared mainly by CYP2D6 and CYP1A2, and rolapitant can inhibit CYP2D6 over a prolonged period. Fluvoxamine concentrations may increase somewhat, with greater nausea, sedation or serotonergic effects, though the clinical effect is probably small.
How serious is the interaction between Fluvoxamine and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for fluvoxamine adverse effects and adjust the dose if they develop.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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