Drug interactions
Fluvoxamine + Silodosin
Severity: Minor
Fluvoxamine and Silodosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP3A4 weakly to moderately and may increase silodosin exposure. Higher levels could increase dizziness and orthostatic hypotension.
What this interaction means in plain words
Fluvoxamine and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Silodosin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated silodosin metabolism by fluvoxamine.
What to do
Monitor for dizziness and orthostatic hypotension after starting fluvoxamine. Reduce silodosin if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Silodosin?
MediHelp rates the interaction as minor. Fluvoxamine and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine inhibits CYP3A4 weakly to moderately and may increase silodosin exposure. Higher levels could increase dizziness and orthostatic hypotension.
How serious is the interaction between Fluvoxamine and Silodosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness and orthostatic hypotension after starting fluvoxamine. Reduce silodosin if symptoms occur.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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