Drug interactions
Fostamatinib + Ivermectin
Severity: Minor
Fostamatinib and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite tamatinib inhibits P-glycoprotein and may increase exposure to ivermectin. Because ivermectin has a wide therapeutic margin, the effect is probably small, but neurological adverse effects are theoretically possible.
What this interaction means in plain words
Fostamatinib and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fostamatinib belongs to Oncology; Ivermectin belongs to Anti Parasitic.
Why it happens
Tamatinib inhibits P-glycoprotein, reducing efflux of ivermectin and raising its absorption and tissue penetration.
What to do
No dose change is usually required for short ivermectin courses. Monitor for dizziness, ataxia or other CNS effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Ivermectin?
MediHelp rates the interaction as minor. Fostamatinib and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite tamatinib inhibits P-glycoprotein and may increase exposure to ivermectin. Because ivermectin has a wide therapeutic margin, the effect is probably small, but neurological adverse effects are theoretically possible.
How serious is the interaction between Fostamatinib and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required for short ivermectin courses. Monitor for dizziness, ataxia or other CNS effects.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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