Drug interactions
Gepirone + Lisdexamfetamine
Severity: Moderate
Gepirone and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines release and block reuptake of monoamines including serotonin, and gepirone is a 5-HT1A agonist antidepressant. Together they may raise the risk of serotonin syndrome, with agitation, tremor, hyperthermia, autonomic instability and neuromuscular hyperactivity.
What this interaction means in plain words
Gepirone and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gepirone belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from amphetamine-induced serotonin release and gepirone 5-HT1A agonism.
What to do
Monitor for signs of serotonin syndrome, particularly at initiation or dose increases. If it occurs, stop the serotonergic agents and give supportive care.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Gepirone and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines release and block reuptake of monoamines including serotonin, and gepirone is a 5-HT1A agonist antidepressant. Together they may raise the risk of serotonin syndrome, with agitation, tremor, hyperthermia, autonomic instability and neuromuscular hyperactivity.
How serious is the interaction between Gepirone and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome, particularly at initiation or dose increases. If it occurs, stop the serotonergic agents and give supportive care.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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