Drug interactions
Givosiran + Haloperidol
Severity: Moderate
Givosiran and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can inhibit CYP2D6, which contributes to haloperidol metabolism, so haloperidol exposure may rise. This could increase extrapyramidal effects and QT prolongation.
What this interaction means in plain words
Givosiran and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Haloperidol belongs to Central Nervous System.
Why it happens
Givosiran-related reduction in CYP2D6 activity decreases haloperidol clearance.
What to do
Monitor for extrapyramidal symptoms, sedation and QTc, and consider a lower haloperidol dose. Use an antipsychotic not dependent on CYP2D6 if problems occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Haloperidol?
MediHelp rates the interaction as moderate. Givosiran and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can inhibit CYP2D6, which contributes to haloperidol metabolism, so haloperidol exposure may rise. This could increase extrapyramidal effects and QT prolongation.
How serious is the interaction between Givosiran and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and QTc, and consider a lower haloperidol dose. Use an antipsychotic not dependent on CYP2D6 if problems occur.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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