Drug interactions
Givosiran + Liposomal doxorubicin
Severity: Minor
Givosiran and Liposomal doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity, and doxorubicin is only a minor CYP2D6 substrate. A meaningful interaction is unlikely.
What this interaction means in plain words
Givosiran and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givosiran belongs to Miscellaneous; Liposomal doxorubicin belongs to Oncology.
Why it happens
Givosiran may reduce CYP2D6 activity, slightly affecting a minor doxorubicin pathway.
What to do
No dose adjustment is needed; monitor routine toxicity parameters.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Liposomal doxorubicin?
MediHelp rates the interaction as minor. Givosiran and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givosiran can reduce CYP2D6 activity, and doxorubicin is only a minor CYP2D6 substrate. A meaningful interaction is unlikely.
How serious is the interaction between Givosiran and Liposomal doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor routine toxicity parameters.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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