Drug interactions
Givosiran + Perphenazine
Severity: Moderate
Givosiran and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity and raise concentrations of sensitive CYP2D6 substrates. Perphenazine is mainly cleared by CYP2D6, so exposure and adverse effects such as sedation, extrapyramidal symptoms, and QT prolongation may increase.
What this interaction means in plain words
Givosiran and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Perphenazine belongs to Central Nervous System.
Why it happens
Givosiran inhibits CYP2D6-mediated metabolism of perphenazine.
What to do
Monitor for perphenazine adverse effects such as extrapyramidal symptoms and sedation, and consider reducing the perphenazine dose. Follow current givosiran labeling for CYP2D6 substrates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Perphenazine?
MediHelp rates the interaction as moderate. Givosiran and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP2D6 activity and raise concentrations of sensitive CYP2D6 substrates. Perphenazine is mainly cleared by CYP2D6, so exposure and adverse effects such as sedation, extrapyramidal symptoms, and QT prolongation may increase.
How serious is the interaction between Givosiran and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for perphenazine adverse effects such as extrapyramidal symptoms and sedation, and consider reducing the perphenazine dose. Follow current givosiran labeling for CYP2D6 substrates.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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