Drug interactions
Givosiran + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Minor
Givosiran and Sofosbuvir-velpatasvir-voxilaprevir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran may reduce CYP1A2 activity and increase exposure to CYP1A2 substrates. Voxilaprevir is mostly cleared via other pathways, so a meaningful effect is unlikely.
What this interaction means in plain words
Givosiran and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givosiran belongs to Miscellaneous; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Givosiran may inhibit CYP1A2, which is a minor route of voxilaprevir metabolism.
What to do
No routine action needed; monitor for adverse effects of the HCV regimen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as minor. Givosiran and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givosiran may reduce CYP1A2 activity and increase exposure to CYP1A2 substrates. Voxilaprevir is mostly cleared via other pathways, so a meaningful effect is unlikely.
How serious is the interaction between Givosiran and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action needed; monitor for adverse effects of the HCV regimen.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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