Drug interactions
Glipizide + Nitisinone
Severity: Moderate
Glipizide and Nitisinone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone inhibits CYP2C9, the main enzyme metabolizing glipizide, and may raise glipizide concentrations. This could increase the risk of hypoglycemia.
What this interaction means in plain words
Glipizide and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Nitisinone belongs to Miscellaneous.
Why it happens
Inhibition of CYP2C9-mediated glipizide metabolism.
What to do
Monitor blood glucose when starting nitisinone and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Frequently asked questions
Can I take Glipizide with Nitisinone?
MediHelp rates the interaction as moderate. Glipizide and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitisinone inhibits CYP2C9, the main enzyme metabolizing glipizide, and may raise glipizide concentrations. This could increase the risk of hypoglycemia.
How serious is the interaction between Glipizide and Nitisinone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting nitisinone and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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