Drug interactions
Glipizide + Posaconazole
Severity: Moderate
Glipizide and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azole antifungals can slow the metabolism of glipizide, increasing its blood-glucose lowering effect. Patients may experience hypoglycemia, which can be prolonged.
What this interaction means in plain words
Glipizide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits hepatic metabolism of glipizide, raising its exposure.
What to do
Increase blood glucose monitoring during co-therapy and after discontinuation of the antifungal. Lower the glipizide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glipizide and Posaconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Posaconazole?
MediHelp rates the interaction as moderate. Glipizide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azole antifungals can slow the metabolism of glipizide, increasing its blood-glucose lowering effect. Patients may experience hypoglycemia, which can be prolonged.
How serious is the interaction between Glipizide and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose monitoring during co-therapy and after discontinuation of the antifungal. Lower the glipizide dose if glucose falls.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
