Drug interactions
Goserelin + Toremifene
Severity: Major
Goserelin and Toremifene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval: androgen deprivation therapy with goserelin is associated with QT prolongation, and toremifene carries a labeled dose-related QT warning. Used together they may produce additive prolongation and raise the risk of torsades de pointes.
What this interaction means in plain words
Goserelin and Toremifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Goserelin belongs to Endocrine; Toremifene belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation through reduced cardiac repolarization reserve.
What to do
Avoid the combination where possible; if both are needed, obtain a baseline ECG and keep potassium and magnesium normal. Repeat ECG monitoring during therapy and stop toremifene if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Goserelin
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Goserelin with Toremifene?
MediHelp rates the interaction as major. Goserelin and Toremifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval: androgen deprivation therapy with goserelin is associated with QT prolongation, and toremifene carries a labeled dose-related QT warning. Used together they may produce additive prolongation and raise the risk of torsades de pointes.
How serious is the interaction between Goserelin and Toremifene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if both are needed, obtain a baseline ECG and keep potassium and magnesium normal. Repeat ECG monitoring during therapy and stop toremifene if QTc becomes markedly prolonged.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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