Drug interactions
Haloperidol + Rolapitant
Severity: Moderate
Haloperidol and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is metabolized partly by CYP2D6 along with CYP3A4, and rolapitant inhibits CYP2D6 for weeks. Haloperidol levels may rise, increasing extrapyramidal effects, sedation and QT prolongation.
What this interaction means in plain words
Haloperidol and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, decreasing haloperidol clearance.
What to do
Monitor for extrapyramidal symptoms and consider an ECG in patients with QT risk factors. Reduce the haloperidol dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Rolapitant?
MediHelp rates the interaction as moderate. Haloperidol and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol is metabolized partly by CYP2D6 along with CYP3A4, and rolapitant inhibits CYP2D6 for weeks. Haloperidol levels may rise, increasing extrapyramidal effects, sedation and QT prolongation.
How serious is the interaction between Haloperidol and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and consider an ECG in patients with QT risk factors. Reduce the haloperidol dose if needed.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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