Drug interactions
Human papillomavirus vaccine + Infliximab
Severity: Moderate
Human papillomavirus vaccine and Infliximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
TNF inhibitors may reduce the antibody response to some vaccines. The HPV vaccine is non-live and safe to give, but the immune response may be diminished.
What this interaction means in plain words
Human papillomavirus vaccine and Infliximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Human papillomavirus vaccine belongs to Miscellaneous; Infliximab belongs to Musculoskeletal.
Why it happens
TNF-alpha blockade impairs immune cell signaling and may dampen the vaccine-induced humoral response.
What to do
Complete HPV vaccination before starting infliximab if feasible; otherwise vaccinate on schedule during therapy and consider immunocompromised dosing recommendations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine with Infliximab?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Infliximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. TNF inhibitors may reduce the antibody response to some vaccines. The HPV vaccine is non-live and safe to give, but the immune response may be diminished.
How serious is the interaction between Human papillomavirus vaccine and Infliximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete HPV vaccination before starting infliximab if feasible; otherwise vaccinate on schedule during therapy and consider immunocompromised dosing recommendations.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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