Drug interactions
Human papillomavirus vaccine + Ocrelizumab
Severity: Moderate
Human papillomavirus vaccine and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ocrelizumab depletes B cells and markedly reduces antibody responses to vaccines. The non-live HPV vaccine is safe but may fail to induce protective immunity.
What this interaction means in plain words
Human papillomavirus vaccine and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Human papillomavirus vaccine belongs to Miscellaneous; Ocrelizumab belongs to Central Nervous System.
Why it happens
Anti-CD20 B-cell depletion impairs humoral response to vaccination.
What to do
Give HPV vaccine at least several weeks before starting ocrelizumab where feasible; if given during therapy, time it before the next infusion and recognize that response may be poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Human papillomavirus vaccine with Ocrelizumab?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ocrelizumab depletes B cells and markedly reduces antibody responses to vaccines. The non-live HPV vaccine is safe but may fail to induce protective immunity.
How serious is the interaction between Human papillomavirus vaccine and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give HPV vaccine at least several weeks before starting ocrelizumab where feasible; if given during therapy, time it before the next infusion and recognize that response may be poor.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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