Drug interactions
Hydrochlorothiazide + Toremifene
Severity: Moderate
Hydrochlorothiazide and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium excretion, and toremifene can cause hypercalcemia in patients with bone metastases. Taking both together may raise the risk of significant hypercalcemia, especially early in toremifene treatment.
What this interaction means in plain words
Hydrochlorothiazide and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Toremifene belongs to Endocrine.
Why it happens
Thiazide-induced increased renal calcium reabsorption adds to toremifene-associated hypercalcemia.
What to do
Measure serum calcium before and during the first weeks of combined therapy. Stop the thiazide or switch to another antihypertensive class if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide with Toremifene?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, and toremifene can cause hypercalcemia in patients with bone metastases. Taking both together may raise the risk of significant hypercalcemia, especially early in toremifene treatment.
How serious is the interaction between Hydrochlorothiazide and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum calcium before and during the first weeks of combined therapy. Stop the thiazide or switch to another antihypertensive class if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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