Drug interactions
Hydrochlorothiazide-irbesartan + Maraviroc
Severity: Minor
Hydrochlorothiazide-irbesartan and Maraviroc: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc has been associated with postural hypotension, particularly in patients with renal impairment or on other blood pressure lowering drugs. Combined with irbesartan and hydrochlorothiazide, the risk of symptomatic hypotension may be increased.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Maraviroc belongs to Anti Virals.
Why it happens
Additive blood pressure lowering; the mechanism of maraviroc-related postural hypotension is not well established.
What to do
Monitor blood pressure and counsel patients about orthostatic symptoms. Adjust antihypertensive doses if hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Maraviroc?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maraviroc has been associated with postural hypotension, particularly in patients with renal impairment or on other blood pressure lowering drugs. Combined with irbesartan and hydrochlorothiazide, the risk of symptomatic hypotension may be increased.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Maraviroc?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel patients about orthostatic symptoms. Adjust antihypertensive doses if hypotension develops.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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