Drug interactions
Hydrochlorothiazide-irbesartan + Toremifene
Severity: Moderate
Hydrochlorothiazide-irbesartan and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene can cause hypercalcemia, particularly in patients with bone metastases, and thiazides reduce urinary calcium excretion, which may worsen this. Toremifene also prolongs the QT interval, and thiazide-related hypokalemia or hypomagnesemia may add to that risk.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Toremifene belongs to Endocrine.
Why it happens
Thiazide reduction of renal calcium excretion adds to toremifene-related hypercalcemia; electrolyte depletion augments QT risk.
What to do
Monitor serum calcium, potassium and magnesium, and correct abnormalities. Consider a non-thiazide antihypertensive if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Toremifene?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Toremifene can cause hypercalcemia, particularly in patients with bone metastases, and thiazides reduce urinary calcium excretion, which may worsen this. Toremifene also prolongs the QT interval, and thiazide-related hypokalemia or hypomagnesemia may add to that risk.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, potassium and magnesium, and correct abnormalities. Consider a non-thiazide antihypertensive if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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