Drug interactions
Hydrochlorothiazide-lisinopril + Porfimer
Severity: Moderate
Hydrochlorothiazide-lisinopril and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a photosensitizing drug and porfimer is a photodynamic therapy agent that causes marked skin photosensitivity. Taking both may intensify photosensitivity reactions such as severe sunburn after light exposure.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Additive photosensitizing effects of two drugs that sensitize skin to light.
What to do
Counsel strict avoidance of sunlight and bright indoor light for the period specified in porfimer labeling. Consider whether the thiazide can be temporarily replaced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Porfimer
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Porfimer?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is a photosensitizing drug and porfimer is a photodynamic therapy agent that causes marked skin photosensitivity. Taking both may intensify photosensitivity reactions such as severe sunburn after light exposure.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict avoidance of sunlight and bright indoor light for the period specified in porfimer labeling. Consider whether the thiazide can be temporarily replaced.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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