Drug interactions
Hydroxycarbamide + Mitomycin
Severity: Moderate
Hydroxycarbamide and Mitomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are myelosuppressive, and mitomycin in particular can cause delayed, cumulative marrow toxicity. Combined use increases the risk of severe cytopenias, infection and bleeding.
What this interaction means in plain words
Hydroxycarbamide and Mitomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxycarbamide belongs to Oncology; Mitomycin belongs to Oncology.
Why it happens
Additive bone marrow suppression from two cytotoxic drugs.
What to do
Check complete blood counts regularly, including after treatment because of delayed nadirs. Reduce doses or delay treatment for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Hydroxycarbamide with Mitomycin?
MediHelp rates the interaction as moderate. Hydroxycarbamide and Mitomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are myelosuppressive, and mitomycin in particular can cause delayed, cumulative marrow toxicity. Combined use increases the risk of severe cytopenias, infection and bleeding.
How serious is the interaction between Hydroxycarbamide and Mitomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check complete blood counts regularly, including after treatment because of delayed nadirs. Reduce doses or delay treatment for significant cytopenias.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine, Stavudine, Adenovirus types 4 and 7 live. The full list is on the Hydroxycarbamide page.
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