Drug interactions
Hydroxychloroquine + Posaconazole
Severity: Major
Hydroxychloroquine and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole and hydroxychloroquine each prolong the QT interval, so the combination can lead to additive effects and a higher risk of torsades de pointes. Risk rises with hypokalemia, hypomagnesemia or structural heart disease.
What this interaction means in plain words
Hydroxychloroquine and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxychloroquine belongs to Musculoskeletal; Posaconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation through repolarization delay.
What to do
Avoid if an alternative exists. If both are needed, check an ECG before and during treatment and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Posaconazole?
MediHelp rates the interaction as major. Hydroxychloroquine and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole and hydroxychloroquine each prolong the QT interval, so the combination can lead to additive effects and a higher risk of torsades de pointes. Risk rises with hypokalemia, hypomagnesemia or structural heart disease.
How serious is the interaction between Hydroxychloroquine and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists. If both are needed, check an ECG before and during treatment and correct potassium and magnesium.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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