Drug interactions
Hyoscyamine + Metoclopramide
Severity: Moderate
Hyoscyamine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is an antimuscarinic that decreases gastrointestinal motility and counteracts the prokinetic effect of metoclopramide. The clinical benefit of metoclopramide may be diminished.
What this interaction means in plain words
Hyoscyamine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hyoscyamine belongs to Genitourinary; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Pharmacodynamic antagonism: antimuscarinic reduction of GI motility opposes metoclopramide's cholinergic prokinetic effect.
What to do
Avoid combining when a prokinetic effect is desired; otherwise monitor for reduced symptom control and adjust therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Metoclopramide?
MediHelp rates the interaction as moderate. Hyoscyamine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine is an antimuscarinic that decreases gastrointestinal motility and counteracts the prokinetic effect of metoclopramide. The clinical benefit of metoclopramide may be diminished.
How serious is the interaction between Hyoscyamine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when a prokinetic effect is desired; otherwise monitor for reduced symptom control and adjust therapy.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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