Drug interactions
Hyoscyamine + Prochlorperazine
Severity: Moderate
Hyoscyamine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is a potent antimuscarinic and prochlorperazine adds further anticholinergic activity. The combination can cause confusion, constipation, urinary retention, tachycardia, dry mouth and heat intolerance.
What this interaction means in plain words
Hyoscyamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hyoscyamine belongs to Genitourinary; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects through pharmacodynamic synergism.
What to do
Monitor for anticholinergic toxicity, especially in older adults, and avoid in those with ileus or urinary retention. Lower the dose of one drug if effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Prochlorperazine?
MediHelp rates the interaction as moderate. Hyoscyamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine is a potent antimuscarinic and prochlorperazine adds further anticholinergic activity. The combination can cause confusion, constipation, urinary retention, tachycardia, dry mouth and heat intolerance.
How serious is the interaction between Hyoscyamine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older adults, and avoid in those with ileus or urinary retention. Lower the dose of one drug if effects develop.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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