Drug interactions
Hyoscyamine + Umeclidinium
Severity: Moderate
Hyoscyamine and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is a systemic antimuscarinic and adds to the effects of inhaled umeclidinium. This increases the risk of dry mouth, constipation, urinary retention, tachycardia and confusion, especially in older adults.
What this interaction means in plain words
Hyoscyamine and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hyoscyamine belongs to Genitourinary; Umeclidinium belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid combining where an alternative exists. Monitor for urinary retention, constipation and cognitive effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Umeclidinium?
MediHelp rates the interaction as moderate. Hyoscyamine and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine is a systemic antimuscarinic and adds to the effects of inhaled umeclidinium. This increases the risk of dry mouth, constipation, urinary retention, tachycardia and confusion, especially in older adults.
How serious is the interaction between Hyoscyamine and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where an alternative exists. Monitor for urinary retention, constipation and cognitive effects.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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