Drug interactions
Idelalisib + Medroxyprogesterone
Severity: Moderate
Idelalisib and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may increase medroxyprogesterone concentrations. This may amplify dose-related progestin effects including thromboembolic risk and fluid retention.
What this interaction means in plain words
Idelalisib and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Medroxyprogesterone belongs to Endocrine.
Why it happens
Idelalisib strongly inhibits CYP3A4, decreasing medroxyprogesterone metabolism.
What to do
Monitor for progestin adverse effects and consider a lower medroxyprogesterone dose. Consider alternatives if high-dose therapy is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Idelalisib and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may increase medroxyprogesterone concentrations. This may amplify dose-related progestin effects including thromboembolic risk and fluid retention.
How serious is the interaction between Idelalisib and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestin adverse effects and consider a lower medroxyprogesterone dose. Consider alternatives if high-dose therapy is used.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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