Drug interactions
Idelalisib + Montelukast
Severity: Minor
Idelalisib and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor, but montelukast is mainly metabolised by CYP2C8, so the effect on its exposure is expected to be small. Montelukast has a wide safety margin, so clinical significance is low.
What this interaction means in plain words
Idelalisib and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Idelalisib belongs to Oncology; Montelukast belongs to Respiratory.
Why it happens
CYP3A4 inhibition by idelalisib affects a minor metabolic pathway of montelukast.
What to do
No routine adjustment is needed; monitor for montelukast adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Montelukast?
MediHelp rates the interaction as minor. Idelalisib and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Idelalisib is a strong CYP3A inhibitor, but montelukast is mainly metabolised by CYP2C8, so the effect on its exposure is expected to be small. Montelukast has a wide safety margin, so clinical significance is low.
How serious is the interaction between Idelalisib and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for montelukast adverse effects.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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