Drug interactions
Idelalisib + Ticlopidine
Severity: Moderate
Idelalisib and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine is a prodrug that depends on hepatic CYP-mediated activation, and its own metabolism involves CYP3A4. Idelalisib is a strong CYP3A inhibitor and can change ticlopidine exposure and activity unpredictably. Ticlopidine also carries serious hematologic and hepatic toxicity, so unpredictable exposure is undesirable.
What this interaction means in plain words
Idelalisib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Ticlopidine belongs to Cardiovascular.
Why it happens
Idelalisib strongly inhibits CYP3A4, which may alter the metabolism of ticlopidine.
What to do
Consider an alternative antiplatelet agent during idelalisib therapy. If both are used, monitor blood counts and liver tests closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Ticlopidine?
MediHelp rates the interaction as moderate. Idelalisib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine is a prodrug that depends on hepatic CYP-mediated activation, and its own metabolism involves CYP3A4. Idelalisib is a strong CYP3A inhibitor and can change ticlopidine exposure and activity unpredictably. Ticlopidine also carries serious hematologic and hepatic toxicity, so unpredictable exposure is undesirable.
How serious is the interaction between Idelalisib and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiplatelet agent during idelalisib therapy. If both are used, monitor blood counts and liver tests closely.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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