Drug interactions
Iloperidone + Rolapitant
Severity: Moderate
Iloperidone and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant is a long-acting CYP2D6 inhibitor and can raise iloperidone concentrations for several weeks after a dose. Higher iloperidone exposure may add to QT prolongation, orthostatic hypotension and sedation.
What this interaction means in plain words
Iloperidone and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, reducing the metabolism of iloperidone.
What to do
Monitor for orthostasis, sedation and QTc prolongation, particularly in patients with other QT risk factors. Consider reducing the iloperidone dose if adverse effects emerge, and remember that the inhibition persists for at least 28 days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Rolapitant?
MediHelp rates the interaction as moderate. Iloperidone and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant is a long-acting CYP2D6 inhibitor and can raise iloperidone concentrations for several weeks after a dose. Higher iloperidone exposure may add to QT prolongation, orthostatic hypotension and sedation.
How serious is the interaction between Iloperidone and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostasis, sedation and QTc prolongation, particularly in patients with other QT risk factors. Consider reducing the iloperidone dose if adverse effects emerge, and remember that the inhibition persists for at least 28 days.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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