Drug interactions
Iloperidone + Silodosin
Severity: Moderate
Iloperidone and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have alpha-1 adrenergic blocking activity. Together they can cause additive orthostatic hypotension, dizziness and syncope, particularly at treatment start or after dose increases.
What this interaction means in plain words
Iloperidone and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iloperidone belongs to Central Nervous System; Silodosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenoceptor antagonism produces vasodilation and hypotension.
What to do
Monitor orthostatic blood pressure when either drug is started or the dose is raised. Titrate iloperidone slowly and advise the patient to change position gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Silodosin?
MediHelp rates the interaction as moderate. Iloperidone and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have alpha-1 adrenergic blocking activity. Together they can cause additive orthostatic hypotension, dizziness and syncope, particularly at treatment start or after dose increases.
How serious is the interaction between Iloperidone and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when either drug is started or the dose is raised. Titrate iloperidone slowly and advise the patient to change position gradually.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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