Drug interactions
Indacaterol + Leuprolide
Severity: Moderate
Indacaterol and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide can prolong the QT interval, and beta-2 agonists can add to arrhythmic risk through hypokalemia and heart rate effects. The combination may increase the chance of torsades de pointes in susceptible patients.
What this interaction means in plain words
Indacaterol and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Leuprolide belongs to Endocrine.
Why it happens
Additive effects on cardiac repolarization and beta-agonist-induced hypokalemia.
What to do
Consider baseline and follow-up ECG in patients with other QT risk factors, and keep potassium and magnesium normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Indacaterol with Leuprolide?
MediHelp rates the interaction as moderate. Indacaterol and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with leuprolide can prolong the QT interval, and beta-2 agonists can add to arrhythmic risk through hypokalemia and heart rate effects. The combination may increase the chance of torsades de pointes in susceptible patients.
How serious is the interaction between Indacaterol and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline and follow-up ECG in patients with other QT risk factors, and keep potassium and magnesium normal.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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