Drug interactions
Indacaterol + Pentamidine
Severity: Moderate
Indacaterol and Pentamidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine can prolong the QT interval and cause torsades de pointes, and it may also disturb electrolytes and glucose. Indacaterol may add to the arrhythmic risk by lowering potassium.
What this interaction means in plain words
Indacaterol and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a possible contributor.
What to do
Monitor ECG and correct potassium and magnesium before and during pentamidine therapy. Seek alternatives if the patient has other major QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Indacaterol with Pentamidine?
MediHelp rates the interaction as moderate. Indacaterol and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentamidine can prolong the QT interval and cause torsades de pointes, and it may also disturb electrolytes and glucose. Indacaterol may add to the arrhythmic risk by lowering potassium.
How serious is the interaction between Indacaterol and Pentamidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium before and during pentamidine therapy. Seek alternatives if the patient has other major QT risk factors.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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