Drug interactions
Indacaterol + Posaconazole
Severity: Moderate
Indacaterol and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can prolong the QT interval, and indacaterol may contribute to arrhythmic risk. Posaconazole also inhibits CYP3A4 and P-gp, which may modestly raise indacaterol exposure.
What this interaction means in plain words
Indacaterol and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol belongs to Respiratory; Posaconazole belongs to Anti Fungals.
Why it happens
Additive QT effects plus inhibition of CYP3A4 and P-gp, increasing indacaterol systemic levels.
What to do
Monitor ECG and QTc, and check potassium and magnesium. Watch for tachycardia, tremor and palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Indacaterol with Posaconazole?
MediHelp rates the interaction as moderate. Indacaterol and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can prolong the QT interval, and indacaterol may contribute to arrhythmic risk. Posaconazole also inhibits CYP3A4 and P-gp, which may modestly raise indacaterol exposure.
How serious is the interaction between Indacaterol and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and QTc, and check potassium and magnesium. Watch for tachycardia, tremor and palpitations.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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