Drug interactions
Infliximab + Lomustine
Severity: Moderate
Infliximab and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine is a myelosuppressive alkylating agent, and infliximab blocks TNF-alpha. Together they can raise the risk of serious bacterial, viral and opportunistic infections beyond that of either drug alone.
What this interaction means in plain words
Infliximab and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Infliximab belongs to Musculoskeletal; Lomustine belongs to Oncology.
Why it happens
Additive immunosuppression from bone marrow suppression (lomustine) and TNF-alpha blockade (infliximab).
What to do
Monitor blood counts and watch closely for signs of infection during combined therapy. Interrupt infliximab and treat promptly if a serious infection or severe neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Infliximab with Lomustine?
MediHelp rates the interaction as moderate. Infliximab and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine is a myelosuppressive alkylating agent, and infliximab blocks TNF-alpha. Together they can raise the risk of serious bacterial, viral and opportunistic infections beyond that of either drug alone.
How serious is the interaction between Infliximab and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch closely for signs of infection during combined therapy. Interrupt infliximab and treat promptly if a serious infection or severe neutropenia develops.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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